The quantitative Gleason score improves prostate cancer risk assessment
نویسندگان
چکیده
منابع مشابه
Protooncogene Bcl-2 and Gleason Score in Prostate Cancer
The aim of this study was to analyse the relationship between the expression of the bcl-2 proto-oncogene and the histological grading of prostate cancer according to the Gleason score. To study the prognostic significance of Bcl-2 over expression in prostate cancer, 36 consecutive radical prostatectomy specimens were examined by immunohistochemistry. Bcl-2 was associated with malignant phenotyp...
متن کاملGleason Score 6 - Prostate Cancer or Benign Variant?
The leading motivation behind wanting to call a 'malignant' prostate lesion 'benign' is the evidence of indolent prostate cancer that is not associated with a fatal outcome and in part makes therapeutic measures such as surgery and radiotherapy appear like overtreatment for some or possibly the majority of such patients. The present article reviews the definitions of 'precancerous lesion' and '...
متن کاملLineage relationship of Gleason patterns in Gleason score 7 prostate cancer.
Gleason score 7 (GS7) prostate cancer [tumors with both Gleason patterns 3 (GP3) and 4 (GP4)] portends a significantly more aggressive tumor than Gleason score 6 (GS6). It is, therefore, critical to understand the molecular relationship of adjacent GP3 and GP4 tumor cell populations and relate molecular abnormalities to disease progression. To decipher molecular relatedness, we used laser captu...
متن کاملPatient risk stratification using Gleason score concordance and upgrading among men with prostate biopsy Gleason score 6 or 7.
PURPOSE To define the impact of discordant Gleason sum (GS) between prostate biopsy (Pbx) tissue and radical prostatectomy (RP) specimen among men initially diagnosed with Gleason 6 or 7 prostate adenocarcinoma. MATERIALS AND METHODS We evaluated patients diagnosed with GS 6 or 7 and treated primarily with RP. We defined the frequency of GS discordance between Pbx and RP pathology reports. We...
متن کاملInterobserver agreement of Gleason score and modified Gleason score in needle biopsy and in surgical specimen of prostate cancer.
INTRODUCTION Gleason score, which has a high interobserver variability, is used to classify prostate cancer. The most recent consensus valued the tertiary Gleason pattern and recommended its use in the final score of needle biopsies (modified Gleason score). This pattern is considered to be of high prognostic value in surgical specimens. This study emphasized the evaluation of the modified scor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer
سال: 2012
ISSN: 0008-543X
DOI: 10.1002/cncr.27670